Prostate clinic > Medications commonly used to treat prostate disorders
Alpha-blockers
Alpha-blockers are used in BPH to help relax the muscles in the bladder and the prostate, which in turn helps to reduce the pressure on the urethra. Side effects include headaches, dizziness and nasal stuffiness.
5-alpha-reductase inhibitors
5-alpha-reductase inhibitors are used in BPH to block the conversion of testosterone to another substance, DHT, which appears to stimulate overgrowth of prostate tissue. Side effects include loss of libido, reduced erections and, rarely, minor breast enlargement.
| 5-alpha-reductase inhibitor | Brand name | Recommended dose |
| Finasteride | Proscar | 5 mg/day |
| Dutasteride | Avodart | 0.5 mg/day |
LHRH analogues
LHRH analogues are used in prostate cancer to ‘switch off’ testosterone production. They also result in loss of sex drive and in hot flushes.
Anti-androgens
Anti-androgens are used in prostate cancer to block the action of testosterone. Side effects include breast tenderness and enlargement.
Anticholinergics and antispasmodics
Anticholinergics and antispasmodics are used in BPH to treat irritative symptoms including urinary frequency and urgency. They may cause a dry mouth and blurred vision.
Vasopressin analogues
Vasopressin analogues are used in BPH to reduce the amount of urine produced at night, thus reducing the need to get out of bed to pass urine. They should not be taken with large amounts of fluid and are not advised for men older than 70 years of age.
| Vasopressin analogue | Brand name | Recommended dose |
| Desmopressin | DDVAP nasal | 10-20 µg at bedtime |
| Desmopressin | Desmospray | 10-20 µg at bedtime |
| Desmopressin | Desmotabs | 200 µg at bedtime |
Other drugs
Anti-inflammatory agents may be given to control pain and inflammation; for example, diclofenac (brand name Voltarol SR) at a dose of 75-100 mg/day. A wide range of antibiotics may be given to treat infection, such as ciprofloxacin (brand name Ciproxin) at a dose of 500 mg twice daily.