| MOLECULAR
GENETIC CHANGES IN PROSTATE CANCER - GUIDES TO CLINICAL MANAGEMENT.
Mark Feneley, Alex Freeman, Magali Williamson, University College, London |
Cancer development and progression are due to the accumulation of genetic changes in cells. Early changes impart a growth advantage and allow the cancer cells to invade and spread through prostate tissue. Eventually the cancer cell acquires the genetic changes necessary to spread outside the prostate. Yet more genetic changes allow the cell to grow in the absence of the male hormone.
This research seeks to define which genetic change controls each step in prostate cancer progression. It will use the large radical prostatectomy database of over 1200 prostate cancer samples (the collection of which is also funded by PRCUK). It will compare the molecular changes in men with good and bad outcomes and try to identify the genetic changes that can be used to help predict the clinical course of individual prostate cancers. It is hoped that the molecular changes can be used to aid the determination of management for any particular cancer.
Research proposal summary dated 19 May 2006
Project 2005/17