| THE
ROLE OF CHROMOSOME TRANSLOCATION IN THE PROGRESSION OF PROSTATE
CANCER.
Dr Yong-Jie Lu St Bartholomew's Hospital and the London School of Medicine |
Chromosome translocation is a genetic event where chromosomes “swop” pieces. It will alter the activity of genes, and therefore plays a key role in the development, progression and even clinical response of many human tumours. However, the role of this process in prostate cancer is largely unknown. Recently these researchers have found a highly frequent chromosome translocation in prostate cancer.
In this research project it is proposed to confirm this finding in a much larger series of prostate cancer samples. It is hoped that these translocations can help predict tumour progression, as the affected patients in this study will be studied for a long time. Ultimately it is hoped these translocations might be used as markers to predict treatment.
Research proposal summary dated 15 May 2006
Project 2005/10