| A
STUDY OF THE TECHNITIUM LABELLED BEMBESIN ANALOGUE, DEMOBESIN-4,
FOR IMAGING OF LYMPH NODE INVOLVEMENT IN PROSTATE CANCER.
Mr Vinod Nargund PhD MS FRCS(Urol) FEBU, Professor Stephen Mather St. Batholomew’s Hospital, and latterly, Cancer Research UK |
The importance of Prostate Cancer to the Western World is not disputed. At the moment there are no definitive investigations for patients who have biochemical failure (their PSA has started to rise again) after supposed curative treatment. The researchers propose to fill this gap by developing an imaging technique for such patients using a new radiotracer, demobesin, which is known to be taken up by prostate cancer cells.
In the laboratory the demobesin can be attached to a radioactive compound,
Technitium. This is administered to the patient who is then scanned to
produce a giant image of the pelvic area. In such nuclear imaging, radioactivity
will highlight any so-called “hot spots” where the demobesin
has been absorbed. This will hopefully provide a means of looking at
the pelvises of patients who have had treatment and should demonstrate
recurrent disease, if this is present.
Research proposal summary dated 15 May 2006
Project 2005/01