| CHARACTERIZATION
OF METASTATIC PROSTATIC CARCINOMA IN BONE IN-SITU HYBRIDIZATION.
A A Bryden, N J R George University of Manchester |
Tragically the primary researcher, Gordon Bryden died shortly after the research finished and he was unable to produce a report. However the in-situ hybridization project was a great success and Mr. Bryden was awarded a Mastership as a consequence. His work has been continued by his colleagues and the unit have developed an increased understanding of the mechanisms of metastasis in bone. His work showed that a "parathyroid hormone-related peptide2" is expressed by prostate cancer and showed how prostate cancer cells secrete an enzyme which breaks down proteins in the host, thereby, facilitating invasion.
Research summary dated 22 May 2006
Project 1997/03